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Ketoacidosis has happened in people who have type 1 diabetes or type 2 diabetes, during treatment with INVOKANA.

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In contrast, an individual with type 2 diabetes may be unaware of the disease process for years prior to being diagnosed.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient.

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May be used in combination with repaglinide if hyperglycemia is not adequately controlled with diet, exercise, and monotherapy with another oral antidiabetic agent.

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On July 1, 2009, the FDA issued an early communication regarding a possible increased risk of cancer in patients using insulin glargine (Lantus).

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The medical evidence of a benefit, however, is limited, because these studies had small samples and were performed at single centers.

However, a large randomized trial of more than 600 women found that clomiphene is superior to metformin in achieving live birth in infertile women with PCOS, with no statistical benefit to the addition of metformin to clomiphene.

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